alexa An epidemic of dengue hemorrhagic fever and dengue shock syndrome in children in Delhi.


Journal of Blood Disorders & Transfusion

Author(s): Aggarwal A, Chandra J, Aneja S, Patwari AK, Dutta AK

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Abstract OBJECTIVE: To study clinical profiles and outcome of children of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) during 1996 Delhi epidemic. DESIGN: Retrospective study. SETTING: Hospital based study. METHODS: Children hospitalized from September to November 1996 were studied. All patients were diagnosed, managed and monitored according to a standard protocol. RESULTS: One hundred and thirty four children (80 (60\%) males and 54 (40\%) females) were studied. Sixty (45\%) children were less than 6 years of age of which 12 presented during infancy. There were 92 (67\%) cases of DHF and 42 (33\%) cases of DSS. Common symptoms were fever (93\%), abdominal pain (49\%) and vomiting (68\%). The commonest hemorrhagic manifestation was hematemesis (39\%) followed by epistaxis (36\%) and skin bleeds (33\%). Hepatomegaly was observed in 97 (72\%) cases and splenomegaly in 25 (19\%). Serology was positive (IgM hemaglutination antibody titres > 1: 160) for dengue type 2 in 31 (80\%) of 39 patients in whom sera was tested during the acute phase of illness. Mortality was 6\%. Hematocrit > 40\% was observed in only 25 (18\%) patients and hence the management protocol was based on clinical signs and symptoms and not on hematocrit. CONCLUSIONS: A management protocol of DHF/DSS in which fluid therapy is not based on haematocrit values needs to be formulated.
This article was published in Indian Pediatr and referenced in Journal of Blood Disorders & Transfusion

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