alexa An evaluation of automated methods for measurement of serum 25-hydroxyvitamin D.
Nephrology

Nephrology

Journal of Nephrology & Therapeutics

Author(s): Wagner D, Hanwell HE, Vieth R

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Abstract OBJECTIVES: To compare two new automated assays with the well-established reference method, DiaSorin radioimmunoassay (RIA), for quantitation of serum total 25-hydroxyvitamin D [25(OH)D]. METHODS: 25(OH)D from human sera (n=158) was measured using DiaSorin RIA and two automated platforms, DiaSorin "LIAISON 25 OH Vitamin D TOTAL", and Roche Modular "Vitamin D3 (25-OH)". Methods were compared by regression and Bland-Altman analyses. RESULTS: DiaSorin LIAISON demonstrated a stronger correlation (r=0.918) and better agreement (bias=-0.88 nmol/L) with DiaSorin RIA than the Roche Modular assay (r=0.871, bias=-2.55 nmol/L). Precision ranges (CV\%) for the RIA, LIAISON, and Roche Modular assays, respectively, were: within run (6.8-12.9\%, 2.8-8.1\%, and 1.9-5.5\%), and total precision (7.4-14.5\%, 7.3-17.5\%, and 7.6-14.5\%). CONCLUSION: DiaSorin LIAISON displayed the best correlation and agreement with DiaSorin RIA. The DiaSorin LIAISON 25 OH Vitamin D TOTAL assay is an accurate and precise automated tool for serum total 25(OH)D determination. This article was published in Clin Biochem and referenced in Journal of Nephrology & Therapeutics

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