alexa An imaginative approach to synovitis--the role of hypoxic reperfusion damage in arthritis.


Rheumatology: Current Research

Author(s): Edmonds SE, Blake DR, Morris CJ, Winyard PG

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Abstract The rheumatoid joint is hypoxic. The loss of the physiologic defense mechanism, reflex muscle inhibition, allows the generation of high intraarticular pressures, particularly during exercise. Hypoxia alters the biochemistry of the synovium and encourages the production of reactive oxygen species (ROS) on reperfusion of blood. In excess, ROS damage tissues, and the products of oxidative damage are detectable in rheumatoid synovial fluid. In addition to damaging proteins, carbohydrates and lipids, cellular and structural damage also occurs.
This article was published in J Rheumatol Suppl and referenced in Rheumatology: Current Research

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