alexa An outbreak of Francisella tularensis in captive prairie dogs: an immunohistochemical analysis.
General Science

General Science

Journal of Bioterrorism & Biodefense

Author(s): Zeidner NS, Carter LG, Monteneiri JA, Petersen JM, Schriefer M,

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Abstract An immunohistochemical assay was developed and tested for detection of Francisella tularensis lipopolysaccaride antigen in tissues of captive prairie dogs (Cynomys ludovicianus). Tissues from 59 cases of F. tularensis were examined by this technique, which was corroborated by direct fluorescent antibody assay and direct isolation of the organism. In infected prairie dogs, studies indicated multiple, severe, necroprurulent foci occurring in the liver, lung, spleen, terminal ileum, and mandibular lymph node. Immunohistochemical analysis of the same formalin-fixed tissues indicated the presence of F. tularensis antigen in neutrophils and macrophages of these lesions and occurring extracellularly in areas of necrosis. This report demonstrates that immunohistochemical analysis is a rapid procedure that can be used to determine the pathogenesis of F. tularensis in rodent populations.
This article was published in J Vet Diagn Invest and referenced in Journal of Bioterrorism & Biodefense

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