alexa An overview of adjuvant formulations and delivery systems
Infectious Diseases

Infectious Diseases

Journal of Infectious Diseases & Therapy

Author(s): Alexis Garca, Juan B De Sanctis

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Adjuvants may promote immune responses: by recruiting professional antigen-presenting cells (APCs) to the vaccination site, increasing the delivery of antigens to APCs, or by activating APCs to produce cytokines and by triggering T cell responses. Aluminium salts have been effective at promoting protective humoral immunity; however, they are not effective in generating cell-mediated immunity. A number of different approaches have been developed to potentiate immune response and they have been partially successful. Research has been conducted into vaccine delivery systems (VDS); enhancing cross-presentation by targeting antigens to (APCs). Antigen discovery has increased over the past decade, and consequently, it has accelerated vaccine development demanding a new generation of VDS that combines different types of adjuvants into specific formulations with greater activity. The new approaches offer a wide spectrum of opportunities in vaccine research with direct applications in the near future.

This article was published in Acta Pathologica, Microbiologica et Immunologica Scandinavica and referenced in Journal of Infectious Diseases & Therapy

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