alexa An overview of adjuvant formulations and delivery systems.
Infectious Diseases

Infectious Diseases

Journal of Infectious Diseases & Therapy

Author(s): Garca A, De Sanctis JB

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Abstract Adjuvants may promote immune responses: by recruiting professional antigen-presenting cells (APCs) to the vaccination site, increasing the delivery of antigens to APCs, or by activating APCs to produce cytokines and by triggering T cell responses. Aluminium salts have been effective at promoting protective humoral immunity; however, they are not effective in generating cell-mediated immunity. A number of different approaches have been developed to potentiate immune response and they have been partially successful. Research has been conducted into vaccine delivery systems (VDS); enhancing cross-presentation by targeting antigens to (APCs). Antigen discovery has increased over the past decade, and consequently, it has accelerated vaccine development demanding a new generation of VDS that combines different types of adjuvants into specific formulations with greater activity. The new approaches offer a wide spectrum of opportunities in vaccine research with direct applications in the near future. © 2013 APMIS. Published by John Wiley & Sons Ltd. This article was published in APMIS and referenced in Journal of Infectious Diseases & Therapy

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