alexa An update on the anticancer effects of a combination of chemotherapy and hyperthermia.


Bioceramics Development and Applications

Author(s): Bull JM

Abstract Share this page

Abstract Hyperthermia combined with chemotherapy is a complicated and poorly understood area, but one that portends great biological and clinical interest. The interrelationship of heat to vascular supply of tumor and normal organs that metabolize chemotherapy agents is complicated. The evocation of thermotolerance by chemical agents is a largely unexplored area. A class of chemotherapy agents that increase in cytotoxicity linearly with increasing temperature are the alkylating agents cisplatinum, mitomycin C, and mitoxantrone. A class of chemotherapy agents that increase in cytotoxicity only after a threshold temperature above 42 degrees are Adriamycin, bleomycin, and actinomycin D. Time sequencing of heat and Adriamycin affects cytotoxicity, implying a membrane effect of the heat and drug interaction. A new class of drugs thought not to be chemotherapy drugs because they are not cytotoxic at 37 degrees but are cytotoxic at greater than 41.5 degrees provides a new area of research. Chemotherapy agents that do not change in cytotoxicity with heat include the Vinca alkaloids, amsacrine, and 5-fluorouracil. In order to examine the complex interaction of heat and chemotherapy agents, whole animal models of tumor and normal tissue effects are extremely important.
This article was published in Cancer Res and referenced in Bioceramics Development and Applications

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version