Author(s): Espy RD, BaduTawiah A, Cooks RG
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Abstract The analysis and modification of surfaces in their native conditions can be performed using new mass spectrometric methods. Ambient ionization sources, including desorption electrospray ionization (DESI), have been implemented for the rapid analysis of unmodified biological surfaces including whole plant material, tissue sections, algae, and bacterial colonies. Recent advances have shown promise for in vivo and high-throughput clinical analysis. Additionally, the recent development of ambient ion soft landing (SL) allows polyatomic ions to be deposited onto surfaces in open air. Ambient SL offers speed, control, and flexibility for surface reactions and modification. Copyright © 2011 Elsevier Ltd. All rights reserved.
This article was published in Curr Opin Chem Biol
and referenced in Journal of Analytical & Bioanalytical Techniques