Author(s): Kuramitsu HK, Smorawinska M, Nakano YJ, Shimamura A, Lis M
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Abstract Glucan synthesis by Streptococcus mutans GS-5 has been analyzed by examining the regulation of expression and structure-function relationships of the glucosyltransferases. Primer extension analysis of the gtf genes has identified the putative promoter sequences for these genes and indicated that the -10 sequences are similar to the Escherichia coli consensus sequence. Site-directed mutagenesis as well as deletion analysis of the enzymes have identified amino acid residues as well as functional domains which play important roles in glucan synthesis.
This article was published in Dev Biol Stand
and referenced in Clinical Depression