alexa Analysis of liver enzymes in albino rat under stress of -cyhalothrin and nuvan toxicity


Journal of Clinical Toxicology

Author(s): HN Sharma

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Toxicity in humans is a threatening truth and much more than any disease caused by any organism as toxic substances are everywhere- in air, in water and in food. Many compounds which are essential to use for human welfare are injurious to us in every manner. Some are used as food additives and other daily use materials. However, there are some compounds which are not directly used by humans but indirectly they enter in human body and induce injuries. Pesticides are very common in these categories which are used against various pests for human welfare but they are also harmful to us via food chain. Liver is the primary site for any toxic substance and suffered first. Further, liver plays very important role in mammalian metabolism. So that any change in liver systematics will definitely affect complete metabolism of an animal. The toxic effect of -cyhalothrin and nuvan has been observed in albino rat through liver enzymes aspartate transaminase (AST) and alanine transaminase (ALT) as they are liver function enzymes and reflects functioning of liver. LD50 of -cyhalothrin and nuvan has been found to be 78mg/kg body weight and 53mg/kg body weight respectively. AST and ALT level in liver has been decreased due to toxic stress induced by these compounds. Effect is more in nuvan treated rats. It is suggested that pyrethroids will be preferred for indoor use instead of nuvan where exposure chances are more for humans.

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This article was published in Biology and Medicine and referenced in Journal of Clinical Toxicology

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