alexa Analysis of Various Subsets of Circulating Mononuclear Cells in Asymptomatic Coronary Artery Disease.


Clinical & Medical Biochemistry

Author(s): Berezin AE, Kremzer AA

Abstract Share this page

Abstract The objective of this study was to evaluate the correlation between multiple cardiovascular risk factors (MCRFs) and circulating mononuclear cells (CMCs) in asymptomatic coronary artery disease patients. DESIGN AND METHODS: 126 subjects (54 male), aged 48 to 62 years, with asymptomatic coronary artery disease (CAD) documented previously with angiography, and 25 healthy volunteers were enrolled in the study. The flow cytometric technique was used for predictably distinguishing cell subsets that depend on the expression of CD14, CD34, Tie-2, CD45, and CD309 (VEGFR2). RESULTS: The analysis of the outcome obtained shows a trend of an increase in circulating CD45(-)CD34(+) CMCs and a reduction in CMC population defined as CD14(+)CD309(+) and CD14(+)CD309(+)Tie(2+) in known asymptomatic CAD patients in comparison with healthy volunteers. Substantial correlations between CD45(-)CD34(+) and conventional cardiovascular risk factors (hs-CRP, T2DM, serum uric acid and hypertension) were found in the patient cohort. The concentrations of CD14(+)CD309(+) and CD14(+)CD309(+)Tie(2+) CMCs had effect on such factors as T2DM (RR = 1.21; 95\% CI = 1.10-1.40; p = 0.008), hs-CRP > 2.54 mg/L (RR = 1.29; 95\% CI = 1.12-1.58; p = 0.006), Agatston score index (RR = 1.20; 95\% CI = 1.15-1.27; p = 0.034), and occurrence of three and more cardiovascular risk factors (RR = 1.31; 95\% CI = 1.12-1.49; p = 0.008). CONCLUSION: It is postulated that the reduction in circulating CD14(+)CD309(+) and CD14(+)CD309(+)Tei(2+) CMCs is related to a number of cardiovascular risk factors in asymptomatic patients with known CAD.
This article was published in J Clin Med and referenced in Clinical & Medical Biochemistry

Relevant Expert PPTs

Recommended Conferences

  • 7th International Conference on Predictive, Preventive and Personalized Medicine & Molecular Diagnostics
    Oct 23-25, 2017 Chicago, USA
  • International Conference on Biotech Pharmaceuticals
    October 23-25, 2017 Paris, France

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version