Author(s): Bardor M, Cabrera G, Rudd PM, Dwek RA, Cremata JA,
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Abstract Plants are attractive hosts for the production of recombinant proteins. However, their inability to process authentic human N-glycan structures imposes a major limitation on their use as expression systems for therapeutic products. Several strategies have emerged to engineer plant N-glycans into human-compatible molecules. In this context, fast and reliable analytical strategies for the identification of plant N-glycan profiles have been developed to define the N-glycosylation pathways of crops, to monitor the production of plant-made pharmaceuticals and to assess in planta remodelling strategies.
This article was published in Curr Opin Struct Biol
and referenced in Journal of Clinical & Cellular Immunology