alexa Angiotropic neonatal congenital melanocytic nevus: how extravascular migration of melanocytes may explain the development of congenital nevi.


Journal of Pigmentary Disorders

Author(s): Barnhill RL, Chastain MA, Jerdan MS, Lebb C, Janin A,

Abstract Share this page

Abstract In the following report we describe a medium-sized congenital melanocytic nevus (CMN) on the upper back of a female patient biopsied at 9 days of age. This case is a unique variant of CMN occurring in the neonatal period that mimics malignant melanoma. This is not only because of histologic features such as a large round or ovoid cellular phenotype of melanocytes mimicking melanoma cells but also because of conspicuous angiotropism, a finding not previously reported in such CMN. Immunostaining for blood and lymphatic vessels demonstrated angiotropism of melanocytes about blood vessels but not lymphatics. We have already emphasized the significance of angiotropism as a marker of extravascular migratory metastasis (EVMM) of melanoma. EVMM, a process by which tumor cells migrate along vessels and other tracks, has striking parallels with the migration of embryonic stem cells from the neural crest. Thus we propose, because angiotropism is a common finding in CMN and metastatic melanoma, that (1) such pathways of cellular migration may result in the genesis of CMN and other melanocytic neoplasms; and (2) the dysregulation of such embryonic pathways may result in the retrograde migratory phenomena of melanoma as already described. In summary, extravascular cellular migration of melanocytes seems to be fundamental for melanoma (perhaps other cancer) metastasis but also hypothetically may be important for the development of other melanocytic lesions such as CMN and requires further investigation. This article was published in Am J Dermatopathol and referenced in Journal of Pigmentary Disorders

Relevant Expert PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version