Author(s): Frisch SM, Screaton RA
Abstract Share this page
Abstract Anoikis is defined as apoptosis that is induced by inadequate or inappropriate cell-matrix interactions. It is involved in a wide diversity of tissue-homeostatic, developmental and oncogenic processes. The central problem of anoikis is to understand how integrin-mediated cell adhesion signals control the apoptotic machinery. In particular, the initiation of the caspase cascade in anoikis remains to be explained.
This article was published in Curr Opin Cell Biol
and referenced in Journal of Carcinogenesis & Mutagenesis