alexa Anorectal and inguinal lymphogranuloma venereum among men who have sex with men in Amsterdam, The Netherlands: trends over time, symptomatology and concurrent infections.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): de Vrieze NH, van Rooijen M, Schim van der Loeff MF, de Vries HJ, de Vrieze NH, van Rooijen M, Schim van der Loeff MF, de Vries HJ

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Abstract OBJECTIVES: To examine lymphogranuloma venereum (LGV) trends over time among men who have sex with men (MSM) visiting the Amsterdam sexually transmitted infection (STI) clinic; to investigate anal LGV symptomatology; and to examine the positivity and characteristics of anorectal and inguinal LGV. METHODS: We included MSM consultations from whom a swab (from anorectum, bubo or an genital ulcer) was taken for Chlamydia trachomatis (Ct) screening. Anorectal swabs were taken from all MSM who reported receptive anorectal intercourse in the preceding 6 months. Ct positive samples were further tested with a pmpH PCR to identify L-genovars. Patient symptoms, clinical and anoscopic inflammatory signs, and STI co-infections were noted; Gram-stained anorectal mucosal smears were examined. RESULTS: Between January 2005 and June 2012, 48 570 consultations among MSM were conducted. In 3628/35 650 visits, anorectal Ct infections were diagnosed, including 411 anal LGV (1.2\%). Moreover, 65/1649 genital ulcer swabs were Ct positive; 10 were inguinal LGV (0.6\%) Since January 2011 a significant increase in the positivity of LGV occurred (p<0.0001). 89 (27.2\%) anorectal LGV cases were asymptomatic. HIV prevalence among anorectal LGV cases was significantly higher (p=0.008) than among inguinal LGV cases. STI co-morbidity in anorectal LGV cases remained invariably high during the study period. CONCLUSIONS: Since January 2011, LGV positivity in MSM consultations in Amsterdam has risen significantly. The great majority comprise anal LGV; inguinal LGV is rare. Anal LGV is asymptomatic in a quarter of cases. In all MSM with anal Ct infections LGV should be excluded, irrespective of symptoms or inflammatory signs. This article was published in Sex Transm Infect and referenced in Journal of AIDS & Clinical Research

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