alexa Antenatal use of ambroxol for the prevention of infant respiratory distress syndrome.


Journal of Neonatal Biology

Author(s): LaoagFernandez JB, Fernandez AM, Maruo T

Abstract Share this page

Abstract OBJECTIVE: Our purpose was to evaluate the efficacy and safety of ambroxol for the prenatal prophylaxis of infant respiratory distress syndrome (IRDS). STUDY DESIGN: This was a prospective study with 2 groups of pregnant patients with premature labor or with premature rupture of membranes at an estimated gestation between 27 to 34 completed weeks. Ambroxol treatment group consisted of 39 subjects in whom 1,000 mg of ambroxol diluted in 500 ml of 5\% glucose solution was given intravenously for 4 hours once a day for 3 days, while the control group consisted of 41 subjects in whom ambroxol was not administered. Main measures included Apgar scores, clinical signs of one or more of the following: respiratory rate of > 60/min, intercostal retraction, alar flaring, expiratory grunting, cyanosis on room air and radiological evidence of IRDS. Chi-square test was used to determine the statistical significance of the results. RESULTS: Tolerable maternal side effects were noted. Profile of newborns delivered were similar in both groups. Incidence of IRDS was significantly less in the treatment group (p < 0.01). CONCLUSIONS: Antenatal administration of ambroxol resulted in a significant decrease in the incidence of IRDS as well as perinatal morbidity and mortality. Due to the efficacy and safety of this drug, it might be useful for the prevention of IRDS.
This article was published in J Obstet Gynaecol Res and referenced in Journal of Neonatal Biology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 29th World Neonatal Nursing and Maternal Healthcare Congress
    August 28-30, 2017 Philadelphia, Pennsylvania, USA
  • 2nd International Conference on Pediatric Neurology
    August 31-September 01, 2017 Prague, Czech Republic
  • 10th World Pediatric Congress
    September 28-29, 2017 Dubai, UAE
  • Infancy, Child Nutrition & Development (ICND)
    October 16-18, 2017 (20 Forums, 3 Days- 1 Event) New York, USA
  • 20th International Conference on Neonatology and Perinatology
    December 04-06, 2017 Madrid, Spain

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version