alexa Antiangiogenic activity of nasunin, an antioxidant anthocyanin, in eggplant peels.


Journal of Traditional Medicine & Clinical Naturopathy

Author(s): Matsubara K, Kaneyuki T, Miyake T, Mori M, Matsubara K, Kaneyuki T, Miyake T, Mori M

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Abstract Nasunin, delphinidin-3-(p-coumaroylrutinoside)-5-glucoside, an antioxidant anthocyanin isolated from eggplant peels, was demonstrated as an angiogenesis inhibitor. Nasunin at higher 10 microM suppressed microvessel outgrowth in an ex vivo angiogenesis assay using a rat aortic ring. The effect of nasunin was examined in various in vitro angiogenesis models using human umbilical vein endothelial cells (HUVECs). Nasunin suppressed HUVEC proliferation in a dose-dependent manner (50-200 microM); however, it had no significant effect on HUVEC chemotaxis in a Boyden chamber assay and HUVEC tube formation on a reconstituted basement membrane. These results imply that nasunin with both antioxidant and antiangiogenic activities might be useful to prevent angiogenesis-related diseases. This article was published in J Agric Food Chem and referenced in Journal of Traditional Medicine & Clinical Naturopathy

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