alexa Antiangiogenic therapy using nanotechnological-based delivery system.


Journal of Cancer Science & Therapy

Author(s): Kanwar JR, Mahidhara G, Kanwar RK, Kanwar JR, Mahidhara G, Kanwar RK

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Abstract Of the many approaches for the treatment of cancer, angiogenesis and the additional promotion of apoptosis in cancer stem cells by using combinatorial therapy is usually the most recommended. There has been increased interest in the use of antiapoptotic and antiangiogenic biomolecules, such as antiangiogenic microRNA, small interfering RNA, inhibitor of apoptosis protein-binding peptides and Von Hippel-Lindau tumor suppressors, as well as targeting ligands, such as aptamers. Therefore, it is tempting to suggest that such molecules could be used for anticancer therapy. As we review here, such exploitation can be achieved by using nanotechnology and RNA-carrying cationic cell-penetrating peptides, for better protection from the enzymatic digestion and enhanced cellular internalization of these biomolecules. Copyright © 2011 Elsevier Ltd. All rights reserved. This article was published in Drug Discov Today and referenced in Journal of Cancer Science & Therapy

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