alexa Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract PAF and allergen-induced bronchial obstruction in vivo.


Journal of Alzheimers Disease & Parkinsonism

Author(s): Dorsch W, Wagner H, Bayer T, Fessler B, Hein G, , Dorsch W, Wagner H, Bayer T, Fessler B, Hein G,

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Abstract Five alk(en)ylsulfinothioic acid alk(en)yl-esters isolated from onions and four synthetic thiosulfinates inhibited 5-lipoxygenase of porcine leucocytes, histamine release and leukotriene B4 and C4 biosynthesis of human polymorphonuclear leucocytes, thromboxane B2 biosynthesis by human platelets and allergen- and PAF-induced bronchial obstruction of guinea-pigs. The anti-asthmatic and anti-inflammatory effects of onions depend in part on the thiosulfinate moiety: (Formula: see text).
This article was published in Biochem Pharmacol and referenced in Journal of Alzheimers Disease & Parkinsonism

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