alexa Antibiotics and the post-genome revolution.
Biochemistry

Biochemistry

Enzyme Engineering

Author(s): Amini S, Tavazoie S

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Abstract The emergence of pathogenic bacteria resistant to multiple antimicrobial agents is turning into a major crisis in human and veterinary medicine. This necessitates a serious re-evaluation of our approaches toward antibacterial drug discovery and use. Concurrent advances in genomics including whole-genome sequencing, genotyping, and gene expression profiling have the potential to transform our basic understanding of antimicrobial pathways and lead to the discovery of novel targets and therapeutics. Copyright © 2011 Elsevier Ltd. All rights reserved. This article was published in Curr Opin Microbiol and referenced in Enzyme Engineering

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