Author(s): Howard MK, Gull K, Miles MA
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Abstract Sera from a total of 268 patients with protozoan, helminth, bacterial (leprosy and tuberculosis) infections or appropriate controls, were assayed for anti-tubulin antibodies in an indirect enzyme-linked immunosorbent assay (ELISA), using purified tubulin as antigen. Levels of serum anti-tubulin antibody were significantly elevated in 67\% of patients with visceral leishmaniasis, in 60\% of patients with cutaneous leishmaniasis, in 89\% of patients with onchocerciasis, in 100\% of patients with schistosomiasis, and in 94\% of patients with leprosy. Little or no increase in anti-tubulin antibody levels was seen in sera from patients with malaria (Plasmodium vivax) or tuberculosis.
This article was published in Clin Exp Immunol
and referenced in Journal of Addiction Research & Therapy