alexa Antibody-reactive epitope determination with HLAMatchmaker and its clinical applications.
Clinical Research

Clinical Research

Journal of Clinical and Experimental Transplantation

Author(s): Duquesnoy RJ

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Abstract Antibodies against allogeneic human leukocyte antigen (HLA) molecules are important impediments to the success of different clinical procedures including transplantation and platelet transfusion. In these settings, characterization of the repertoire of immunogenic epitopes is important for permissible mismatch determination and the identification of acceptable mismatches for sensitized patients. HLAMatchmaker is a computer algorithm that considers small configurations of polymorphic residues referred to as eplets as essential components of HLA epitopes. This review critically elaborates the concepts underlying the HLAMatchmaker and describes the usefulness of HLAMatchmaker in the clinical setting. Recent developments have increased our understanding of structural basis of HLA antigenicity (i.e. reactivity with specific antibody) and immunogenicity (i.e. its ability to induce an antibody response). © 2011 John Wiley & Sons A/S. This article was published in Tissue Antigens and referenced in Journal of Clinical and Experimental Transplantation

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