alexa Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants.
Psychiatry

Psychiatry

Journal of Addiction Research & Therapy

Author(s): Thring TS, Hili P, Naughton DP

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Abstract BACKGROUND: Owing to their roles in tissue remodelling in health and disease, several studies have reported investigations on plant extracts as inhibitors of proteinases and as anti-oxidants. METHODS: The anti-ageing and anti-oxidant properties of 23 plant extracts (from 21 plant species) were assessed as anti-elastase and anti-collagenase activities and in selected anti-oxidant assays along with phenolic content. RESULTS: Anti-elastase activities were observed for nine of the extracts with inhibitory activity in the following order: white tea (approximately 89\%), cleavers (approximately 58\%), burdock root (approximately 51\%), bladderwrack (approximately 50\%), anise and angelica (approximately 32\%). Anti-collagenase activities were exhibited by sixteen plants of which the highest activity was seen in white tea (approximately 87\%), green tea (approximately 47\%), rose tincture (approximately 41\%), and lavender (approximately 31\%). Nine plant extracts had activities against both elastase (E) and collagenase (C) and were ranked in the order of white tea (E:89\%, C:87\%) > bladderwrack (E:50\%, C:25\%) > cleavers (E:58\%, C:7\%) > rose tincture (E:22\%, C:41\%) > green tea (E:10\%: C:47\%) > rose aqueous (E: 24\%, C:26\%) > angelica (E:32\%, C:17\%) > anise (E:32\%, C:6\%) > pomegranate (E:15\%, C:11\%).Total phenolic content varied between 0.05 and 0.26 mg gallic acid equivalents (GAE)/mL with the exception of white tea (0.77 mg GAE/mL). For anti-oxidant assessment, the Trolox equivalent anti-oxidant capacity (TEAC) assay revealed activity for all extracts. White tea had the highest activity equivalent to approximately 21 microM Trolox for a 6.25 microg aliquot. In addition, seven extracts exhibited activities = 10 microM Trolox with witch hazel (6.25 microg = 13 microM Trolox) and rose aqueous (6.25 microg = 10 microM Trolox) showing very high activities at low concentrations. A high activity for white tea was also found in the superoxide dismutase (SOD) assay in which it exhibited ~88\% inhibition of reduction of nitroblue tetrazolium. High activities were also observed for green tea (86.41\%), rose tincture (82.77\%), witch hazel (82.05\%) and rose aqueous (73.86\%). CONCLUSION: From a panel of twenty three plant extracts, some one dozen exhibit high or satisfactory anti-collagenase or anti-elastase activities, with nine having inhibitory activity against both enzymes. These included white tea which was found to have very high phenolic content, along with high TEAC and SOD activities.
This article was published in BMC Complement Altern Med and referenced in Journal of Addiction Research & Therapy

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