alexa Anti-demineralization effect of a novel fluoride-releasing varnish on dentin.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Shiiya T, Mukai Y, Tomiyama K, Teranaka T

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Abstract PURPOSE: To investigate the laboratory anti-demineralization effect of a novel fluoride-releasing varnish containing surface reaction-type prereacted glass-ionomer (S-PRG) filler. METHODS: Paired specimens were cut from bovine root dentin. One of each pair was used for the S-PRG group, and the other served as a control (n = 6). A 1 x 3 mm test surface was made on each specimen with the fluoride-releasing varnish. The novel fluoride-releasing varnish is categorized as a two-bottle-type self-etch adhesive. These liquids were mixed, applied on the test surface, and light-cured for 10 seconds. As a control, an S-PRG filler-free varnish was applied in the same manner. Each specimen was immersed in 8\% methylcellulose gel demineralization system (1.5 mM Ca, 0.9 mM PO4, 0.1 M acetic acid, pH 5.0) for 7 days at 3 degrees C. The mineral profiles and integrated mineral loss (IML) of the lesions were obtained by transversal microradiography and analytical software. RESULTS: The S-PRG group exhibited significantly thicker surface layer than the control group. Furthermore, the S-PRG group showed significantly lower IML (3,459 vol\% xmicropm) than the control group (4,687 vol\% xmicropm) ( P < 0.05, Welch's two-sample t-test). The novel fluoride-releasing varnish increased acid resistance of root dentin in the vicinity of the coated surface.
This article was published in Am J Dent and referenced in Pharmaceutica Analytica Acta

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