Author(s): Preda A, MacLean RW, Mazure CM, Bowers MB Jr, Preda A, MacLean RW, Mazure CM, Bowers MB Jr, Preda A, MacLean RW, Mazure CM, Bowers MB Jr
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Abstract BACKGROUND: The safety and tolerability of the selective serotonin reuptake inhibitors and the newer atypical agents have led to a significant increase in antidepressant use. These changes raise concern as to the likelihood of a corresponding increase in adverse behavioral reactions attributable to these drugs. METHOD: All admissions to a university-based general hospital psychiatric unit during a 14-month period were reviewed. RESULTS: Forty-three (8.1\%) of 533 patients were found to have been admitted owing to antidepressant-associated mania or psychosis. CONCLUSION: Despite the positive changes in the side effect profile of antidepressant drugs, the rate of admissions due to antidepressant-associated adverse behavioral effects remains significant.
This article was published in J Clin Psychiatry
and referenced in Epidemiology: Open Access