Author(s): Preda A, MacLean RW, Mazure CM, Bowers MB Jr, Preda A, MacLean RW, Mazure CM, Bowers MB Jr, Preda A, MacLean RW, Mazure CM, Bowers MB Jr, Preda A, MacLean RW, Mazure CM, Bowers MB Jr
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Abstract BACKGROUND: The safety and tolerability of the selective serotonin reuptake inhibitors and the newer atypical agents have led to a significant increase in antidepressant use. These changes raise concern as to the likelihood of a corresponding increase in adverse behavioral reactions attributable to these drugs. METHOD: All admissions to a university-based general hospital psychiatric unit during a 14-month period were reviewed. RESULTS: Forty-three (8.1\%) of 533 patients were found to have been admitted owing to antidepressant-associated mania or psychosis. CONCLUSION: Despite the positive changes in the side effect profile of antidepressant drugs, the rate of admissions due to antidepressant-associated adverse behavioral effects remains significant.
This article was published in J Clin Psychiatry
and referenced in Epidemiology: Open Access