alexa Antidiabetic and hypolipidemic effects of different fractions of Coccinia cordifolia L. on normal and streptozotocin-induced diabetic rats.
Nutrition

Nutrition

Journal of Nutritional Disorders & Therapy

Author(s): Islam MA, Khan MR, Hossain MS, Alam AH, IbneWahed MI, , Islam MA, Khan MR, Hossain MS, Alam AH, IbneWahed MI, , Islam MA, Khan MR, Hossain MS, Alam AH, IbneWahed MI, , Islam MA, Khan MR, Hossain MS, Alam AH, IbneWahed MI,

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Abstract The present study was carried out to observe the antidiabetic and hypolipidemic effects of petroleum-ether, ethyl acetate and chloroform fractions isolated from ethanolic extract of the leaves of Coccinia cordifolia Linn. (150 mg/kg body weight) on normal and streptozotocin (STZ)-induced diabetic rats for one day experiment. Single doses (150 mg/kg, i.p.) of C. cordifolia extracts were given to normal and diabetic rats. The fasting blood glucose (FBG), serum triglyceride (TG) and serum total cholesterol (TC) levels were investigated in normal and STZ-diabetic rats on 0, 1, 2, 3, 6, 10, 16, and 24th hours. In normoglycemic rats the pet-ether and ethyl acetate fractions of C. cordifolia reduced blood glucose level significantly (39.66\% and 40.68\% at 16th and 24th hour respectively). In the STZ-diabetic rats pet-ether and ethyl acetate fractions also reduced blood glucose level significantly (50.39\% and 50\% at 10th and 24th hour respectively). Ethyl acetate fraction is most effective which reduced total cholesterol level by 31.04\% and 36.69\% in normal and STZ-diabetic rats respectively. Ethyl acetate fraction reduced triglyceride level by 43.82\% and 42.01\% in normal and STZ-diabetic rats respectively. Our results indicate that pet-ether and ethyl acetate fractions of C. cordifolia have potentiality against diabetes.
This article was published in Pak J Pharm Sci and referenced in Journal of Nutritional Disorders & Therapy

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