alexa Antifungal mechanism of hinokitiol against Candida albicans.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Clinical & Experimental Pharmacology

Author(s): Komaki N, Watanabe T, Ogasawara A, Sato N, Mikami T, , Komaki N, Watanabe T, Ogasawara A, Sato N, Mikami T,

Abstract Share this page

Abstract The growth of Candida albicans was dose-dependently inhibited by addition of hinokitiol. The sensitivity of C. albicans to hinokitiol under aerobic conditions was higher than that under anaerobic conditions. Amount of ATP in C. albicans was not inhibited by hinokitiol under both conditions. The expression of mRNAs related to the growth signal, CYR1 and RAS1, was inhibited by hinokitiol. These findings suggested that the growth inhibition of C. albicans by hinokitiol was due to the interruption of RAS-signal transmission, such as the cAMP pathway.
This article was published in Biol Pharm Bull and referenced in Journal of Clinical & Experimental Pharmacology

Relevant Expert PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version