alexa Antihirsutism activity of Fennel (fruits of Foeniculum vulgare) extract. A double-blind placebo controlled study.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Javidnia K, Dastgheib L, Mohammadi Samani S, Nasiri A

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Abstract Idiopathic hirsutism is defined as the occurrence of excessive male pattern hair growth in women who have a normal ovulatory menstrual cycle and normal levels of serum androgens. It may be a disorder of peripheral androgen metabolism. In this study we evaluated the clinical response of idiopathic hirsutism to topical Fennel extract. Fennel, Foeniculum vulgare, is a plant, which has been used as an estrogenic agent. The ethanolic extract of Fennel was obtained by using a soxhlete apparatus. In a double blind study, 38 patients were treated with creams containing 1\%, 2\% of Fennel extract and placebo. Hair diameter was measured and rate of growth was considered. The efficacy of treatment with the cream containing 2\% Fennel is better than the cream containing 1\% Fennel and these two were more potent than placebo. The mean values of hair diameter reduction was 7.8\%, 18.3\% and -0.5\% for patients receiving the creams containing 1\%, 2\% and 0\% (placebo) respectively. This article was published in Phytomedicine and referenced in Pharmaceutica Analytica Acta

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