alexa Anti-inflammatory and analgesic activities of methanolic extract of Kigelia pinnata DC flower.


Medicinal Chemistry

Author(s): William Carey M, Rao NV, Kumar BR, Mohan GK

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Abstract ETHNOPHARMACOLOGICAL RELEVANCE: Kigelia pinnata DC is extensively used in Indian traditional medicine for several diseases including inflammatory and painful disorders. AIM OF THE STUDY: The aim of the present study is to investigate the possible anti-inflammatory and analgesic activities of methanolic extract of Kigelia pinnata flower (MKFL) to support the medicinal uses claimed by folklore practitioners. MATERIALS AND METHODS: MKFL is evaluated for its anti-inflammatory activity in carrageenan-induced paw edema model in rats and analgesic activity in acetic acid-induced writhing, hot plate and formalin-induced paw licking models in mice. RESULTS: MKFL exhibited a significant (P<0.01) anti-inflammatory and analgesic activities with the doses of 100, 200 and 400mg/kg b.w. in rats and mice respectively. CONCLUSIONS: The results of the experimental study thus strongly support the traditional use of this plant for inflammatory and pain disorders. Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved. This article was published in J Ethnopharmacol and referenced in Medicinal Chemistry

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