alexa Antimicrobial resistance of Staphylococcus aureus: genetic basis


Clinical Microbiology: Open Access

Author(s): B R Lyon, R Skurray

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In recent years, there has been a dramatic increase in the incidence of hospital-associated (nosocomial) infections caused by strains of Staphylococcus aureus that are resistant to multiple antibiotics; some strains now demonstrate resistance to as many as 20 antimicrobial compounds, including antiseptics and disinfectants. The threat to patient care posed by such organisms, largely due to their intransigence to antimicrobial chemotherapy, has stimulated efforts to gain insights into the genetic nature of the determinants encoding antibiotic resistance and the mechanisms by which they spread in staphylococcal populations. Attention is also being directed towards understanding the processes and pathways for the evolution of resistance in S. aureus. These studies have benefited, significantly, from the application of the powerful techniques of molecular genetics and have led to an explosion in the information on staphylococcal resistance since the last review devoted to this topic appeared in this journal (255). In this article, we have placed greatest emphasis on the molecular and genetic nature of resistance determinants but have also included brief descriptions of the resistance mechanisms they encode. Recent reviews which include some discussion of the genetics of antibiotic resistance in staphylococci are those by Foster (142), Poston and Naidoo (392), Brunton (55), Lacey (259

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This article was published in Microbiol Rev and referenced in Clinical Microbiology: Open Access

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