alexa Antimicrobial resistance of Staphylococcus aureus: genetic basis
Microbiology

Microbiology

Clinical Microbiology: Open Access

Author(s): B R Lyon, R Skurray

Abstract Share this page

In recent years, there has been a dramatic increase in the incidence of hospital-associated (nosocomial) infections caused by strains of Staphylococcus aureus that are resistant to multiple antibiotics; some strains now demonstrate resistance to as many as 20 antimicrobial compounds, including antiseptics and disinfectants. The threat to patient care posed by such organisms, largely due to their intransigence to antimicrobial chemotherapy, has stimulated efforts to gain insights into the genetic nature of the determinants encoding antibiotic resistance and the mechanisms by which they spread in staphylococcal populations. Attention is also being directed towards understanding the processes and pathways for the evolution of resistance in S. aureus. These studies have benefited, significantly, from the application of the powerful techniques of molecular genetics and have led to an explosion in the information on staphylococcal resistance since the last review devoted to this topic appeared in this journal (255). In this article, we have placed greatest emphasis on the molecular and genetic nature of resistance determinants but have also included brief descriptions of the resistance mechanisms they encode. Recent reviews which include some discussion of the genetics of antibiotic resistance in staphylococci are those by Foster (142), Poston and Naidoo (392), Brunton (55), Lacey (259

  • To read the full article Visit
  • Open Access
This article was published in Microbiol Rev and referenced in Clinical Microbiology: Open Access

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords