alexa Antimicrobial susceptibility among Acinetobacter calcoaceticus-baumannii complex and Enterobacteriaceae collected as part of the Tigecycline Evaluation and Surveillance Trial.
Materials Science

Materials Science

Journal of Nanomedicine & Nanotechnology

Author(s): Halstead DC, Abid J, Dowzicky MJ

Abstract Share this page

Abstract OBJECTIVE: To measure the in vitro activity of a panel of antimicrobial agents against gram-negative pathogens collected from the nine census regions of the USA. METHODS: Isolates were collected from 76 centers between January 2004 and September 2005. In vitro activity was assessed using CLSI guidelines and CLSI or FDA interpretive criteria. RESULTS: The lowest overall antimicrobial susceptibilities for Acinetobacter calcoaceticus-baumannii complex isolates (n=851) were detected in the Middle Atlantic and East South Central regions. Overall, 29.3\% of A. calcoaceticus-baumannii complex isolates were multidrug-resistant (resistant to > or =3 antimicrobial classes). Tigecycline (2 microg/mL) had the lowest MIC90 against this organism. Imipenem, tigecycline, and levofloxacin had low MIC90s (0.25-4 microg/mL) against Enterobacter spp. (n=1557), although the MIC90 for levofloxacin was elevated for East South Central region isolates (> or = 16 microg/mL). Susceptibility to levofloxacin among the E. coli isolates (n=1785) ranged from 71.7\% (Pacific) to 88.5\% (New England). The prevalence of ESBL-producing K. pneumoniae (126/1460) varied from 1.7\% of isolates (Pacific) to 21.2\% (Middle Atlantic). ESBL-producing K. pneumoniae MICs were lowest for imipenem and tigecycline. CONCLUSIONS: Antimicrobial susceptibility varies among the census regions of the USA. The broad-spectrum in vitro activity of tigecycline may make it a suitable candidate for use in the empiric treatment of serious infections. This article was published in J Infect and referenced in Journal of Nanomedicine & Nanotechnology

Relevant Expert PPTs

Recommended Conferences

  • Nano Congress for Next Generation
    August 31-September 01, 2017 Brussels,Belgium
  • Graphene & 2D Materials
    September 14-15, 2017 Edinburgh, Scotland
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version