alexa Antimutagenic activity of extracts of leaves of four common edible vegetable plants in Nigeria (west Africa).
Chemical Engineering

Chemical Engineering

Journal of Chromatography & Separation Techniques

Author(s): ObaseikiEbor EE, Odukoya K, Telikepalli H, Mitscher LA, Shankel DM

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Abstract Organic solvent extracts of leaves of 4 common edible vegetable plants--Bryophyllum pinnatum, Dialium guincense, Ocimum gratissimum and Vernonia amygdalina--had inhibitory activity for His- to His+ reverse-mutations induced by ethyl methanesulfonate acting on Salmonella typhimurium TA100. The concentrated ethyl acetate, methanol and petroleum ether extracts were heat-stable when dissolved in dimethyl sulfoxide. The Bryophyllum ethyl acetate extract was fractionated into alkaloidal/water-soluble, acids, polar lipid and non-polar lipid fractions. The polar and non-polar lipid fractions inhibited reversion mutations induced by ethyl methanesulfonate acting on TA100 or TA102, and were also active against reversions induced by 4-nitro-O-phenylenediamine and 2-aminofluorene in TA98. The alkaloidal/water-soluble and the acid fractions had no appreciable antimutagenic activities.
This article was published in Mutat Res and referenced in Journal of Chromatography & Separation Techniques

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