alexa Anti-mutagenic chalcones: antagonizing the mutagenicity of benzo(a)pyrene on Salmonella typhimurium.


Modern Chemistry & Applications

Author(s): Torigoe T, Arisawa M, Itoh S, Fujiu M, Maruyama HB

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Abstract Several chalcone derivatives; e.g. Ro 09-0204, Ro 09-0323 and Ro 09-0501 were found to reduce markedly the revertant increase of Salmonella typhimurium TA100 by benzo(a)pyrene during the incubation with S-9 Mix. The antimutagenic activity was 100 - 700 times stronger than that of L-ascorbic acid. Effect on other mutagens, the structure activity relationship and the possible mechanism of action are briefly discussed.
This article was published in Biochem Biophys Res Commun and referenced in Modern Chemistry & Applications

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