alexa Anti-mycobacterial activity of a bis-sulfonamide.


Organic Chemistry: Current Research

Author(s): Wilkinson BL, Bornaghi LF, Wright AD, Houston TA, Poulsen SA

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Abstract A bis-arylsulfonamide, 7, has been identified that exhibits growth inhibition of Mycobacterium smegmatis at less than 25 microg/mL, but has no such activity against Escherichia coli or Staphylococcus aureus. A closely related bis-arylsulfonamide (8) was much less active, but was the only other compound among 54 arylsulfonamides tested with detectable growth inhibition of M. smegmatis. This article was published in Bioorg Med Chem Lett and referenced in Organic Chemistry: Current Research

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