alexa Anti-neoplastic effect of halocynthiaxanthin, a metabolite of fucoxanthin.
Geology & Earth Science

Geology & Earth Science

Journal of Oceanography and Marine Research

Author(s): Nishino H, Tsushima M, Matsuno T, Tanaka Y, Okuzumi J,

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Abstract We have reported that fucoxanthin, a natural carotenoid, inhibited the growth of human neuroblastoma GOTO cells. In the present study, we show that a metabolite of fucoxanthin, halocynthiaxanthin, which is isolated from sea squirt Halocynthia roretzi, has a more potent inhibitory effect. Halocynthiaxanthin (5 micrograms/ml) caused complete suppression of GOTO cell proliferation, whereas fucoxanthin reduced the growth rate by only 88.8\% compared with the control, at day 2 after the drug treatment. Furthermore, halocynthiaxanthin also inhibited the growth of other human malignant tumor cells. Thus halocynthiaxanthin seems to be a promising anti-neoplastic agent.
This article was published in Anticancer Drugs and referenced in Journal of Oceanography and Marine Research

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