alexa Antiplatelet drug discontinuation is a risk factor for ischemic stroke.


Journal of Blood Disorders & Transfusion

Author(s): Sibon I, Orgogozo JM

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Abstract Antiplatelet drugs (APD) are widely used in the prevention of ischemic cardio- and cerebrovascular diseases. The authors studied the frequency of stroke occurring after APD discontinuation, the cause of discontinuation, and the delay between APD disruption and stroke. Only 4.49\% of strokes were related to a recent APD discontinuation, but all cases occurred between 6 and 10 days after drug discontinuation (p < 0.0001). This temporal pattern has biologic plausibility because the inhibited platelets circulate in the blood for about 10 days.
This article was published in Neurology and referenced in Journal of Blood Disorders & Transfusion

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