Author(s): Rothschild BM, Sebes JI, Rothschild C
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Abstract OBJECTIVE: Determination of the antiquity of spondyloarthropathy by examining the fossil record. METHODS: Fossil collections from the Paleocene and Eocene of North America were systematically examined to determine the occurrence and population frequency of spondyloarthropathy. RESULTS: Spondyloarthropathy was present in three mammalian orders dated at 30 to 50 million years. The frequency was 13\% to 50\% in the affected genera. CONCLUSIONS: Erosive arthritis of the spondyloarthropathy variety is now documented to have originated at least 40 million years ago in the Paleocene.
This article was published in Clin Exp Rheumatol
and referenced in Journal of Antivirals & Antiretrovirals