alexa Antiretroviral durability and tolerability in HIV-infected adults living in urban Kenya.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Hawkins C, Achenbach C, Fryda W, Ngare D, Murphy R, Hawkins C, Achenbach C, Fryda W, Ngare D, Murphy R

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Abstract BACKGROUND: Insufficient data exist on the durability and tolerability of first-line antiretroviral therapy (ART) regimens provided by HIV treatment programs implemented in developing countries. METHODS: Longitudinal observation of clinical, immunologic, and treatment parameters of all HIV-infected adult patients initiated on ART was performed at Saint Mary's Mission Hospital in Nairobi, Kenya from September 2004 until August 2006. RESULTS: A total of 1286 patients were analyzed (59.1\% female). Initial ART regimens were primarily stavudine, lamivudine, and nevirapine (62.1\%). Median ART duration was 350 days (11.6 months). Significant improvements in clinical and immunologic status were noted after 12 months of therapy. ART switches occurred in 701 (54.5\%) patients. The cumulative incidence of ART switch at 12 months was 78.4\%. Concurrent ART-related toxicities (40.6\%) and tuberculosis treatment interactions (28.1\%) were the most frequent reasons for ART switch. Baseline AIDS symptoms (hazard rate [HR]=1.59, 95\% confidence interval [CI]: 1.28 to 1.98; P<0.01) and a CD4 count
  • DOI: 10.1097/QAI.0b013e318050d66c
  • This article was published in J Acquir Immune Defic Syndr and referenced in Journal of AIDS & Clinical Research

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