alexa Antitumor agents. Part 204: synthesis and biological evaluation of substituted 2-aryl quinazolinones


Journal of Chemical Biology & Therapeutics

Author(s): Xia Y, Yang ZY, Hour MJ, Kuo SC, Xia P, Bastow K, Nakanishi Y, Namrpoothiri P, Hackl T, Hamel E, Lee HK

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A series of 2',3',4',6,7-substituted 2-aryl quinazolinones were synthesized and evaluated for biological activity. Among them, 17 displayed significant growth inhibitory action against a panel of tumor cell lines. Compound 17 was also a potent inhibitor of tubulin polymerization. Compounds 8-10 displayed selective activity against P-gp-expressing epidermoid carcinoma of the asopharynx.

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This article was published in Bioorg Med Chem Lett and referenced in Journal of Chemical Biology & Therapeutics

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