alexa Antivirulence potential of TR-700 and clindamycin on clinical isolates of Staphylococcus aureus producing phenol-soluble modulins.
Clinical Research

Clinical Research

JBR Journal of Clinical Diagnosis and Research

Author(s): Yamaki J, Synold T, WongBeringer A

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Abstract Staphylococcus aureus strains (n = 50) causing complicated skin and skin structure infections produced various levels of phenol-soluble modulin alpha-type (PSMα) peptides; some produced more than twice that produced by the control strain (LAC USA300). TR-700 (oxazolidinone) and clindamycin strongly inhibited PSM production at one-half the MIC but exhibited weak to modest induction at one-fourth and one-eighth the MICs, primarily in low producers. Adequate dosing of these agents is emphasized to minimize the potential for paradoxical induction of virulence.
This article was published in Antimicrob Agents Chemother and referenced in JBR Journal of Clinical Diagnosis and Research

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