alexa Apicomplexan parasites and subversion of the host cell microRNA pathway.


Journal of Neuroinfectious Diseases

Author(s): Hakimi MA, Cannella D, Hakimi MA, Cannella D

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Abstract RNA silencing plays a major role in innate antiviral and antibacterial defenses in plants, insects, and animals through the action of microRNAs (miRNAs). miRNAs can act in favor of the microorganism, either when it is pathogen-encoded or when the microorganism subverts host miRNAs to its benefit. Recent data point to the possibility that apicomplexan parasites have developed tactics to interfere with host miRNA populations in a parasite-specific manner, thereby identifying the RNA-silencing pathway as a new means to reshape their cellular environment. This review highlights the current understanding and new insights concerning the mechanisms that could be involved and the potential roles of the host microRNome (miRNome) in apicomplexan infection. Copyright © 2011 Elsevier Ltd. All rights reserved. This article was published in Trends Parasitol and referenced in Journal of Neuroinfectious Diseases

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