alexa Apoptosis Induced by Staphylococcus aureus in Epithelial Cells Utilizes a Mechanism Involving Caspases 8 and 3


Journal of Bacteriology & Parasitology

Author(s): Kenneth W Bayles

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In this study, we demonstrate that the mechanism by whichStaphylococcus aureus induces apoptosis in bovine mammary epithelial (MAC-T) cells involves caspases 8 and 3, two key components of a proteolytic cascade leading to apoptosis. In addition, internalized S. aureus induces expression of the inflammatory cytokines tumor necrosis factor alpha and interleukin-1β by MAC-T cells. These data suggest that the internalization of S. aureus could induce specific cellular responses in vivo that may ultimately impact the course of infection.

This article was published in Infection and Immunity and referenced in Journal of Bacteriology & Parasitology

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