Author(s): Tang D, Lotze MT, Kang R, Zeh HJ
Abstract Share this page
Abstract One hallmark of cancer is intrinsic or acquired resistance to apoptosis. Surprisingly, recent studies demonstrate that CD95/Fas/Apo1 and p53 upregulated mediator of apoptosis/PUMA (potent inducers of the death receptor and the mitochondrial apoptotic pathways, respectively) promote tumorigenesis. These findings provide important insights into the multifaceted roles of apoptosis in tumorigenesis.
This article was published in Oncogene
and referenced in Journal of Cell Science & Therapy