alexa Aptamer-based therapeutics of the past, present and future: from the perspective of eye-related diseases.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Molecular Biomarkers & Diagnosis

Author(s): Kanwar JR, Shankaranarayanan JS, Gurudevan S, Kanwar RK

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Abstract Aptamers have emerged as a novel and powerful class of biomolecules with an immense untapped potential. The ability to synthesise highly specific aptamers against any molecular target make them a vital cog in the design of effective therapeutics for the future. However, only a minutia of the enormous potential of this dynamic class of molecule has been exploited. Several aptamers have been studied for the treatment of eye-related disorders, and one such strategy has been successful in therapy. This review gives an account of several eye diseases and their regulatory biomolecules where other nucleic acid therapeutics have been attempted with limited success and how aptamers, with their exceptional flexibility to chemical modifications, can overcome those inherent shortcomings. Copyright © 2014 Elsevier Ltd. All rights reserved. This article was published in Drug Discov Today and referenced in Journal of Molecular Biomarkers & Diagnosis

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