Author(s): Raphael John Ogbe, Adenkola Adeshina, Emmanuel Anefu
This study was conducted to evaluate the effect of aqueous ethanolic extract of Mangifera indica stem bark on the biochemical and haematological indices of adult albino Wistar rats, so as to determine how safe the extract is in animals. Ten rats were separated into two groups, the first group served as control while the second group was administered 5000 mg/kg body weight of the extract by orogastric intubation for 14 days. The results showed that there was significant elevation (p < 0.05) in the obtained values of white blood cells count, lymphocytes, monocytes, neutrophils, red blood cells and packed cell volume in the treated rats when compared with the control. There was also a significant (p < 0.05) increase in the serum levels of Aspartate transaminase, Albumin and Alanine transaminase in the treated rats when compared with the control. These suggest that the aqueous ethanolic extract of M.indica stem bark might have immunostimulating properties, may also stimulate the haematopoietic system and reduce oxidative damage of red blood cell membranes but may be slowly injurious to hepatic tissues of animals at high doses and prolonged duration of treatment.