alexa Are anti-Helicobacter pylori urease antibodies involved in atherosclerotic diseases?
Microbiology

Microbiology

Clinical Microbiology: Open Access

Author(s): Arabski M, Konieczna I, Soowiej D, Rogo A, Kolesiska B

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OBJECTIVES: The ureB subunit of urease is a major target recognized by the antibodies of Helicobacter pylori-infected patients. The minimal epitope was determined to be an 8-mer peptide (H-SIKEDVQF-OH). DESIGN AND METHODS: The aim of this study was to discover whether this synthetic 8-mer peptide (BK-61A) directly recognizes the anti-ureB subunit antibodies of H. pylori-infected and atherosclerotic patients. To achieve a better presentation of the epitopes to antibodies, a new isocyanuric linker was designed and used for to immobilize the peptides on a cellulose support. RESULTS: In this study a new peptide synthesis method is presented. Anti-ureB antibodies were evaluated by the dot blot technique in 26 H. pylori-infected donors and the sera of 20 H. pylori-infected patients with atherosclerosis using the 8-mer peptide. CONCLUSIONS: The results reveal that the BK-61A peptide could be used for diagnosing the presence of anti-ureB antibodies that may be involved in the initiation of atherosclerosis.

This article was published in Clin Biochem and referenced in Clinical Microbiology: Open Access

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