alexa Assembly of microarrays for genome-wide measurement of DNA copy number.
Biomedical Sciences

Biomedical Sciences

International Journal of Biomedical Data Mining

Author(s): Snijders AM, Nowak N, Segraves R, Blackwood S, Brown N,

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Abstract We have assembled arrays of approximately 2,400 BAC clones for measurement of DNA copy number across the human genome. The arrays provide precise measurement (s.d. of log2 ratios=0.05-0.10) in cell lines and clinical material, so that we can reliably detect and quantify high-level amplifications and single-copy alterations in diploid, polyploid and heterogeneous backgrounds. This article was published in Nat Genet and referenced in International Journal of Biomedical Data Mining

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