Author(s): Liao CM, Ju YR, Chen WY, Chen BC
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Abstract The purpose of this study was to use a risk-based integrated-scale toxicological model to examine the impact of waterborne and dietborne cadmium (Cd) toxicity on rainbow trout (Oncorhynchus mykiss) susceptibility appraised with recent published data. A probabilistic assessment model was performed to estimate Cd susceptibility risk. The dose-response models were constructed based on two endpoints of \% Cd in metabolically active pool (MAP) and susceptibility time that causes 50\% effect (ST50). We further constructed an elimination-detoxification-recovery scheme to enhance the model predictive ability. We found a 95\% probability of \% Cd in gill and liver MAP exceeding 47-49\% and it was likely (70\% probability) to have exceeded 52-55\%, but it was unlikely (30\% probability) to have exceeded 56-60\%. In contrast to gill and liver, gut had a relative lower Cd susceptibility risk (15-17\% Cd in MAP) with a longer ST50. We suggested that the proposed probabilistic risk assessment framework can incorporate the elimination-detoxification-recovery scheme to help government based biomonitoring and bioassessment programs to prevent potential aquatic ecosystems and human health consequences. Copyright © 2010 Elsevier B.V. All rights reserved.
This article was published in Sci Total Environ
and referenced in Journal of Aquaculture Research & Development