alexa Assessment of the palatability of vehicles for activated charcoal in pediatric volunteers.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Pharmaceutical Care & Health Systems

Author(s): Dagnone D, Matsui D, Rieder MJ

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Abstract OBJECTIVE: To evaluate the palatability of 4 common flavoring vehicles (water, chocolate milk [CM], orange juice [OJ], and cola) combined with activated charcoal (AC) in pediatric volunteers. DESIGN: A single-blind taste test of 4 different vehicles (water, OJ, a cola drink, and CM) was conducted in healthy volunteer children. Each child tasted 1.25 mL of Charcodote (0.2g/mL) mixed with 1.25 mL of each vehicle. SETTING: Palatability testing was conducted at the office of 1 of the authors. PARTICIPANTS: Thirty children (16 male, 14 female), aged 6.5 +/- 1.4 years (range 5-9 years). OUTCOME MEASURES: After each test dose, each child rated its taste on a modified 10 cm visual analog scale incorporating a facial-hedonic scale. Each child was also asked for his/her overall preference. RESULTS: Taste scores (cm) were as follows: water 5.6 +/- 1.8, OJ 5.4 +/- 1.0, cola 7.6 +/- 0.7, and CM 5.6 +/- 0.8. There was a significant difference in the taste scores between the cola drink (P = 0.01) and the other 3 vehicles. The cola drink was also selected as the most preferred vehicle by 50\% of the children as compared with 19.2\% for CM and 15.4\% for OJ. In contrast, water was selected as the least preferred vehicle by 36.4\% of children versus 31.8\% for CM and 27.3\% for OJ. Only 4 children (15.4\%) stated that water was their preferred vehicle, and only 1 child (4.5\%) stated that cola drink was the least preferred drink. CONCLUSIONS: Children rate the palatability higher and prefer charcoal given with a cola drink rather than with water. OJ and CM do not seem to improve the acceptability of charcoal.
This article was published in Pediatr Emerg Care and referenced in Journal of Pharmaceutical Care & Health Systems

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